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MAO-B Inhibitors

Monoamine Oxidase Type B (MAO-B) is an enzyme in our body that breaks  down brain chemicals such as dopamine. MAO-B inhibitors block the effect of MAO-B to improve many motor symptoms of PD. MAO-B inhibitors are commonly used in early therapy or in addition to other medications to help reduce "off" time and extend "on time." Some studies indicate that MAO-B inhibitors slow the progress of PD by offering neuroprotection. MAO-B inhibitors are used to treat:

  • Slowness

  • Stiffness

  • Tremor

  • "On/Off" fluctuations

The most common side effects of MAO-B inhibitors include:

  • Mild nausea

  • Dry mouth

  • Lightheadedness

  • Constipation

Pharmacists routinely warn about other drug interactions with MAO-B inhibitors, including antidepressants. Prior to starting any MAO-B inhibitor, carefully review all medications, including over the counter medications with your physician for possible adverse reactions. It is also very important to provide information about MAO-B inhibitors to anesthesiologists prior to any surgeries.

Disclaimer: The information provided on this Parkinson Association of Alabama Resource Center is for awareness and educational purposes only about Parkinson's medication. The PAA does not endorse any specific brand or type of medication. All discussions about medication should be between you, your care partner, and your medical teams.


Davis Phinney Foundation. Parkinson's Treatments and Therapies. Chapter 7 - Medication. Page 113. Every Victory Counts. "Manual." Sixth Edition, 2021.

Parkinson's Foundation. Medications: A Treatment Guide to Parkinson's Disease. "Brochure."

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