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Catechol-O-methyl transferase (COMT) is a medication that deactivates levodopa prior to it being absorbed in the bloodstream to get to the brain. This medication can increase the benefit of levodopa, reducing "off" times and lengthening "on" times. They are generally well tolerated, though they may exaggerate some levodopa-related side effects, particularly dyskinesia. Additional side effects may include:

  • Confusion

  • Hallucinations

  • Discoloration of Urine

  • Diarrhea

Disclaimer: The information provided on this Parkinson Association of Alabama Resource Center is for awareness and educational purposes only about Parkinson's medication. The PAA does not endorse any specific brand or type of medication. All discussions about medication should be between you, your care partner, and your medical teams.


Davis Phinney Foundation. Parkinson's Treatments and Therapies. Chapter 7 - Medication. Page 114. Every Victory Counts. "Manual." Sixth Edition, 2021.

Parkinson's Foundation. Medications: A Treatment Guide to Parkinson's Disease. "Brochure."

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