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Amantadine (Symmetrel) is an anti-influenza medication that has been discovered to cause less tremor in PD patients. It often provides immediate benefit for most PD symptoms and can reduce levodopa - induced dyskinesia. It is most commonly available as a capsule, but liquid and tablet formats are also available. The most frequent side effects include:

  • Nausea

  • Dry Mouth

  • Lightheadedness

  • Insomnia

  • Confusion

  • Pedal edema

  • Hallucinations

  • Purple discoloration of skin

Starting and stopping the drug instantly could cause serious withdrawal syndromes. The medication is also available in an extended-release format. These tablets should not be split, crushed, or chewed, unlike other medications. This drug is used most in combination with carbidopa/levodopa for "on/off" fluctuations.


Disclaimer:  The information provided on this Parkinson Association of Alabama Resource Center is for awareness and educational purposes only about Parkinson's medication. The PAA does not endorse any specific brand or type of medication. All discussions about medication should be between you, your care partner, and your medical teams.


Davis Phinney Foundation. Parkinson's Treatments and Therapies. Chapter 7 - Medication. Page 114. Every Victory Counts. "Manual." Sixth Edition, 2021.

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