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Adenosine A2a Antagonists

An adenosine receptor antagonist is a combined treatment with carbidopa/levodopa when experiencing "off" episodes. While it has been proven to reduce "off" time by 30-60 minutes in some patients per day, it can also worsen dyskinesia. It can also contribute to insomnia if taken later in the day.

Disclaimer: The information provided on this Parkinson Association of Alabama Resource Center is for awareness and educational purposes only about Parkinson's medication. The PAA does not endorse any specific brand or type of medication. All discussions about medication should be between you, your care partner, and your medical teams.


Davis Phinney Foundation. Parkinson's Treatments and Therapies. Chapter 7 - Medication. Page 115. Every Victory Counts. "Manual." Sixth Edition, 2021.

Parkinson's Foundation. Medications. A Treatment Guide to Parkinson's Disease. "Brochure."

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