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Gastrointestinal symptoms refer to nausea or constipation. These symptoms can be caused by disease progression and some medications. Managing gastrointestinal disorders in PD can be complicated. Because everyone tolerates medications differently, an additional medication may be needed to help lessen extreme side effects in combination with drug therapies.

Trimethobenzamide (Tigran) and ondansetron (Zofran) are available medications used to treat nausea in PD patients well. Simple antacids or ginger capsules may also be helpful.

One of the most common non-motor symptoms of Parkinson's is constipation and it can severely affect quality of life. Lifestyle changes like increasing water, increasing dietary fiber, and increasing exercise are the cornerstones of treatment. Lowering medications that may have anticholinergic side effects may be necessary. Specific pharmacological interventions are also available. Common side effects include bloating, gas, upset stomach, and dizziness.

Lubiprostone is a common medication prescribed for excessive constipation which increases the secretion of fluid in your intestines to make it easier to pass stool. ​

Disclaimer: The information provided on this Parkinson Association of Alabama Resource Center is for awareness and educational purposes only about Parkinson's medication. The PAA does not endorse any specific brand or type of medication. All discussions about medication should be between you, your care partner, and your medical teams.


Davis Phinney Foundation. Parkinson's Treatments and Therapies. Chapter 7 - Medication. Page 118. Every Victory Counts. "Manual." Sixth Edition, 2021.

Parkinson's Foundation. Medications. A Treatment Guide to Parkinson's Disease. "Brochure."


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