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Constipation and Medications

Constipation can also play a significant role in carbidopa / levodopa absorption and ON-OFF fluctuations. In the digestive system, food makes its way from the mouth to the large intestine through the alimentary canal (esophagus, stomach, and small and large intestines). Sometimes your intestines aren't being emptied regularly. In that case, the carbidopa/levodopa you take won't make its way through the digestive system as it should, and therefore, it cannot control your symptoms most effectively. Staying regular means your carbidopa/levodopa will work most effectively, and you will experience less OFF time.

Disclaimer: The information provided on this Parkinson Association of Alabama Resource Center is for awareness and educational purposes only about Parkinson's medication. The PAA does not endorse any specific brand or type of medication. All discussions about medication should be between you, your care partner, and your medical teams.


Davis Phinney Foundation. Parkinson's Treatments and Therapies. Chapter 7 - Medication. Page 109, Pages 125-131. Every Victory Counts. "Manual." Sixth Edition, 2021.

Marie, Lianna. Medications to Avoid. Chapter 37, page 112. Managing Medication Side Effects. Chapter 33, pages 100-101. Betting the Most Out of Medications. Chapter 35, pages 105-106. The Complete Guide for People with Parkinson's Disease and Their Loved Ones. Lianna Marie. Purdue University Press, (C) 2022.

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